Question 1

One of the most common pathophysiologies that contribute to folic acid deficiency is:

Accepted Answer

A)  Tropical sprue
B)  Intrinsic factor deficiency
C)  IDA
D)  Infection with Diphyllobothrium latumE) A) and B)
F) A) and C) A

Question 2

Which of the following can distinguish treated versus untreated megaloblastic anemia?

Accepted Answer

A)  Polychromasia
B)  Hypochromia
C)  Howell-Jolly bodies
D)  SiderocytesE) A) and B)
F) A) and C)

Question 3

Macrocytic red blood cells are routinely seen in all the following except:

Accepted Answer

A)  Pernicious anemia
B)  Liver disease
C)  Response to anemic stress
D)  ThalassemiaE) A) and B)
F) B) and C)

Question 4

The Schilling test continues to be a historic reference method for the determination of:

Accepted Answer

A)  IDA
B)  Pernicious anemia
C)  Folic acid deficiency
D)  Hereditary hemochromatosisE) A) and C)
F) None of the above

Question 5

Which of the following describes ineffective erythropoiesis?

Accepted Answer

A)  An increase in the M:E ratio
B)  A synthetic defect in hemoglobin
C)  Premature destruction of red blood cell precursors
D)  A DNA maturation defectE) A) and B)
F) A) and C)

Question 6

A macrocytosis that is not megaloblastic in origin can be seen in all of the following except:

Accepted Answer

A)  Chemotherapy
B)  Postsplenectomy
C)  Hypoglycemic patients
D)  ReticulocytosisE) A) and B)
F) None of the above C

Question 7

All of the following are possible causes of low levels of intrinsic factor (IF)  except which statement?

Accepted Answer

A)  Partial gastrectomy may lead to the lack of IF.
B)  Fifty-six percent of patients with pernicious anemia have antibodies to IF.
C)  Atrophic gastritis may lead to the lack of IF.
D)  Kidney failure may lead to lack of IF.E) All of the above
F) A) and C) D

Question 8

Which of the following terms describes the appearance of the erythropoietic precursors in the megaloblastic process?

Accepted Answer

A)  Ordered arrangement of chromatin
B)  Asynchrony
C)  Eccentric nucleus
D)  Pale cytoplasmE) A) and B)
F) None of the above

Question 9

Which of the following is a key substance required for the incorporation of vitamin B12 in the nuclear synthesis of red blood cells?

Accepted Answer

A)  EPO
B)  Transferrin
C)  Intrinsic factor
D)  CytokinesE) A) and C)
F) None of the above

Question 10

Which MCV range is indicative of pernicious anemia?

Accepted Answer

A)  70 to 80 fL
B)  85 to 95 fL
C)  110 to 120 fL
D)  90 to 98 fLE) A) and B)
F) A) and C)

Question 11

What would be an appropriate M:E ratio in the case of megaloblastic anemia?

Accepted Answer

A)  1:3
B)  4:1
C)  5:1
D)  1:10E) B) and D)
F) B) and C)

Question 12

A bone marrow aspiration/examination is not necessary for patients with megaloblastic anemia.

Accepted Answer

A) True 
 B)False

Question 13

Intrinsic factor is secreted by the:

Accepted Answer

A)  Parietal cells of the stomach
B)  Ileum
C)  Thyroid
D)  Bone marrowE) B) and D)
F) A) and B)

Question 14

Which of the following is a clinical symptom specific to megaloblastic anemia?

Accepted Answer

A)  Fever
B)  Numbness and trouble with balance
C)  Pallor
D)  SplenomegalyE) All of the above
F) A) and C)

Question 15

Evidence of ineffective erythropoiesis in the CBC of patients with megaloblastic anemia are:

Accepted Answer

A)  Anemia, thrombocytopenia, leukopenia.
B)  Anemia, thrombocytosis, leukopenia .
C)  Anemia, thrombophilia , leukocytosis
D)  anemia, thrombocytosis, leukopeniaE) None of the above
F) B) and C)

Question 16

Which of the following red blood cell morphologies is classic in the megaloblastic anemias?

Accepted Answer

A)  Polychromasia
B)  Macroovalocytes
C)  Basophilic stippling
D)  HypochromiaE) A) and B)
F) A) and C)

Exam 6: The Macrocytic Anemias

One of the most common pathophysiologies that contribute to folic acid deficiency is:

Correct Answer
verified
A

Which of the following can distinguish treated versus untreated megaloblastic anemia?

Correct Answer
verified

Macrocytic red blood cells are routinely seen in all the following except:

Correct Answer
verified

The Schilling test continues to be a historic reference method for the determination of:

Correct Answer
verified

Which of the following describes ineffective erythropoiesis?

Correct Answer
verified

A macrocytosis that is not megaloblastic in origin can be seen in all of the following except:

Correct Answer
verified
C

All of the following are possible causes of low levels of intrinsic factor (IF) except which statement?

Correct Answer
verified
D

Which of the following terms describes the appearance of the erythropoietic precursors in the megaloblastic process?

Correct Answer
verified

Which of the following is a key substance required for the incorporation of vitamin B₁₂ in the nuclear synthesis of red blood cells?

Correct Answer
verified

Which MCV range is indicative of pernicious anemia?

Correct Answer
verified

What would be an appropriate M:E ratio in the case of megaloblastic anemia?

Correct Answer
verified

A bone marrow aspiration/examination is not necessary for patients with megaloblastic anemia.

Correct Answer
verified

Intrinsic factor is secreted by the:

Correct Answer
verified

Which of the following is a clinical symptom specific to megaloblastic anemia?

Correct Answer
verified

Evidence of ineffective erythropoiesis in the CBC of patients with megaloblastic anemia are:

Correct Answer
verified

Which of the following red blood cell morphologies is classic in the megaloblastic anemias?

Correct Answer
verified

Exam 6: The Macrocytic Anemias

One of the most common pathophysiologies that contribute to folic acid deficiency is:

Correct AnswerverifiedA

Which of the following can distinguish treated versus untreated megaloblastic anemia?

Correct AnswerverifiedShow Answer

Macrocytic red blood cells are routinely seen in all the following except:

Correct AnswerverifiedShow Answer

The Schilling test continues to be a historic reference method for the determination of:

Correct AnswerverifiedShow Answer

Which of the following describes ineffective erythropoiesis?

Correct AnswerverifiedShow Answer

A macrocytosis that is not megaloblastic in origin can be seen in all of the following except:

Correct AnswerverifiedC

All of the following are possible causes of low levels of intrinsic factor (IF) except which statement?

Correct AnswerverifiedD

Which of the following terms describes the appearance of the erythropoietic precursors in the megaloblastic process?

Correct AnswerverifiedShow Answer

Which of the following is a key substance required for the incorporation of vitamin B12 in the nuclear synthesis of red blood cells?

Correct AnswerverifiedShow Answer

Which MCV range is indicative of pernicious anemia?

Correct AnswerverifiedShow Answer

What would be an appropriate M:E ratio in the case of megaloblastic anemia?

Correct AnswerverifiedShow Answer

A bone marrow aspiration/examination is not necessary for patients with megaloblastic anemia.

Correct AnswerverifiedShow Answer

Intrinsic factor is secreted by the:

Correct AnswerverifiedShow Answer

Which of the following is a clinical symptom specific to megaloblastic anemia?

Correct AnswerverifiedShow Answer

Evidence of ineffective erythropoiesis in the CBC of patients with megaloblastic anemia are:

Correct AnswerverifiedShow Answer

Which of the following red blood cell morphologies is classic in the megaloblastic anemias?

Correct AnswerverifiedShow Answer

Correct Answer
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A

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C

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D

Correct Answer
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Which of the following is a key substance required for the incorporation of vitamin B₁₂ in the nuclear synthesis of red blood cells?

Correct Answer
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Correct Answer
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