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Glycolysis traps some of the chemical energy of oxidation as ATP, and the remainder as


A) AMP
B) NADH
C) Ph osp hate
D) FADH2
E) GTP

F) C) and E)
G) D) and E)

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In substrate-level phosphorylation, the phosphate used to make ATP from ADP comes from


A) Inorganic phosphate in the cytoplasm
B) Inorganic phosphate in the matrix of the m itochondria
C) Phosphate in the DNA backbone
D) A phosphorylated metabolic intermediate
E) ADP

F) A) and C)
G) All of the above

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Lactate dehydrogenase


A) Allows for rapid glycolysis and ATP production
B) Converts 2,3 diphosphoglyceric acid into lactic acid
C) Regenerates NAD+ so that rapid glycolysis can continue
D) Converts lactic acid into phosphoenolpyruvic acid
E) Both A and C are true

F) A) and D)
G) A) and C)

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Glycolysis is the process


A) In carbohydrate metabolism that converts glucose to pyruvic acid
B) In carbohydrate metabolism that converts pyruvic acid to CO2
C) In lipid metabolism that converts fatty acids to acetyl CoA
D) In lipid metabolism in which acetyl CoA is oxidized to CO2
E) In amino acid metabolism in which glucose is generated

F) A) and B)
G) A) and C)

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A

Most energy-requiring reactions in the cell obtain their energy from


A) The hydrolysis of the terminal phosphate bond in ATP
B) Thermal energy provided by the heat of the body
C) The energy in the chemical bonds of proteins
D) Proteolys is
E) Glycogenolysis

F) A) and B)
G) B) and D)

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The TCA cycle's main function is to


A) Oxidize acet yl CoA to CO2
B) Make acetyl CoA for synthesis of lipids
C) Produce reducing equivalents as NADH and FADH2
D) Synthesize ATP
E) Both A and C are correct

F) A) and B)
G) All of the above

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The generation of glucose from amino acid precursors is called


A) Glycolysis
B) Glycogenolysis
C) Lipogenesis
D) Gluconeogensis
E) Glucotransformation

F) B) and E)
G) D) and E)

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D

Rapid increases in glycogenolysis in the liver is brought about by


A) Activation of phosphorylase by a signal cascade involving activation of PKA by cAM P
B) Activation of phosphorylase by catalytic receptors on the surface membrane of the hepatocyte
C) Increased synthesis of phosphorylase through nuclear receptors
D) Depolarization of the liver cell, increased cytosolic [Ca2+] and activation of CAM Kinase
E) Activation of a JAK-STAT pathway

F) B) and C)
G) A) and B)

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Which of the following is NOT a source of plasma glucose?


A) Ingested food
B) Free fatty acids
C) Alanine by gluconeogenesis
D) Liver glycogen
E) Glycine, by gluoneogenesis

F) A) and B)
G) All of the above

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Glucose enters muscle and fat cells from the blood by using


A) SGLT1
B) GLUT4
C) A Na+ -glucose exchanger
D) NHE
E) A primary active transport mechanism

F) A) and B)
G) None of the above

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The main function of the electron transport chain is to


A) Oxidize NADH and FADH2 and pump H+ for the generation of ATP
B) Carry electrons back to the beginning of metabolism
C) Transport electrons out of the mitochondria
D) Completely oxidize acetyl CoA
E) Regenerate NADH and FADH2

F) All of the above
G) A) and B)

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A

The enzyme that converts pyruvic acid into lactic acid is


A) Pyruvate dehydrogenase
B) Pyruvate kinase
C) Enolase
D) Phosphoenolpyruvate dehydrogenase
E) Lactate dehydrogenase

F) A) and C)
G) C) and E)

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Glycogenolysis


A) Breaks glycogen down , releasing glucose-1-phosphate
B) Form s glucose from am ino acid precursors
C) Occurs only in the liver
D) Occurs only in muscle
E) Makes glucose available from fatty acids

F) B) and C)
G) None of the above

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Muscle fibers cannot contribute directly to plasma glucose because they lack


A) Phosphorylase
B) Glucokinase
C) Glucose -1 -phosphatase
D) Phosphoglucomutase
E) Glucose-6-phosphatase

F) None of the above
G) A) and B)

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During gluconeogenesis, all of the following are essential EXCEPT


A) Glycolysis runs backwards
B) Amino acids are used to make acetylCoA
C) Am ino acids are used to make oxaloacetate and malate
D) PEP carboxykinase converts oxaloacetate to phosphoenolypyruvate
E) Fructose biphosphatase is activated

F) C) and D)
G) C) and E)

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