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Following transcription,the intron sequences are cut out of the primary transcript and the ends are joined again prior to its use in protein synthesis.This processing of the RNA is called RNA __________.


A) modification
B) translation
C) splicing
D) transcription

E) A) and C)
F) None of the above

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You are constructing a model of the RNA holoeznyme.You should


A) start with the α\alpha subunits and then add the core polymerase consisting of the β\beta β\beta ' σ\sigma subunits.
B) start with the core polymerase consisting of the β\beta β\beta ' subunits and then add the β\beta σ\sigma subunits.
C) start with the core polymerase consisting of the β\beta β\beta ' σ\sigma subunits and then add the α\alpha subunit.
D) start with the core polymerase consisting of the α\alphaβ\beta β\beta ' subunits and then add the σ\sigma subunit.

E) All of the above
F) A) and B)

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Which of the following is not true about eukaryotic DNA?


A) It is an exceedingly long and fragile molecule.
B) It is packaged into successively compact formations.
C) The entire molecule has encoded information for protein synthesis.
D) In the condensed form,it is transcriptionally inactive.
E) It must be unpackaged before it can be transcribed into RNA.

F) C) and D)
G) D) and E)

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How many unique mRNA codons can be constructed from the four different RNA nucleotides?


A) 4
B) 8
C) 16
D) 32
E) 64

F) All of the above
G) A) and D)

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The connection that exists between genes and hereditary traits requires the deciphering of the information encoded in genes into


A) amino acids.
B) nucleotides.
C) proteins.
D) histone molecules.
E) complementary bases.

F) A) and B)
G) A) and E)

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Ribosomes are complex arrangements of


A) RNA and DNA.
B) RNA and large proteins.
C) RNA and sugars.
D) DNA and proteins.
E) nucleosomes and RNA.

F) A) and B)
G) A) and C)

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Specific amino acids are attached to tRNA molecules by


A) activating enzymes.
B) codons.
C) anticodons.
D) ribosomes.
E) initiation factors.

F) C) and E)
G) D) and E)

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The essence of heredity is the ability of cells to use the information in their DNA to bring about the production of particular ________,thereby affecting what the cells will be like.


A) proteins
B) ribosomes
C) RNAs
D) helicases

E) A) and B)
F) C) and D)

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The process that occurs when a ribosome moves three more nucleotides along the mRNA molecule in the 5' to 3' direction is referred to as


A) transduction.
B) translation.
C) translocation.
D) transposon.

E) All of the above
F) A) and D)

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The sites A,P,and E are progressively occupied by amino acids being assembled into a chain in protein synthesis.These sites are part of


A) small ribosomal subunit.
B) large ribosomal subunit.
C) mRNA.
D) tRNA.
E) DNA (the gene itself) .

F) C) and D)
G) A) and D)

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Ribosome movement along the mRNA transcript is called


A) transcription.
B) translation.
C) replication.
D) translocation.
E) mutation.

F) B) and E)
G) All of the above

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Of the types of RNA polymerase that are known,which one is the most complex?


A) I
B) II
C) III
D) IV

E) A) and C)
F) A) and D)

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Most eukaryotic genes contain coding sequences called ________ that are interspersed with noncoding sequences.


A) introns
B) exons
C) codons
D) DNA

E) C) and D)
F) B) and D)

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The initiation complex for protein synthesis contains all of the following except


A) a small ribosomal subunit.
B) mRNA.
C) tRNA with methionine.
D) a release factor.
E) an initiation factor.

F) A) and E)
G) B) and E)

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The results suggest that regulatory region(s) lie


A) between -150 to -120 and between -30 to 0.
B) between -30 and 0 only.
C) between -120 and -30.
D) between -120 to -90,between -30 to 0.

E) All of the above
F) B) and D)

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Similar to the complementary purine-pyrimidine relationship observed in DNA,which of the following choices pairs with adenine in RNA?


A) thymine
B) cytosine
C) guanine
D) uracil

E) A) and B)
F) A) and C)

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The enzyme that initiates transcription is


A) RNA polymerase.
B) DNA polymerase.
C) carbonic anhydrase.
D) ATP synthetase.
E) transformation principlE.

F) C) and D)
G) B) and D)

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The expression of a gene involves two phases,___________ and translation.


A) replication
B) transcription
C) unwinding
D) condensation

E) A) and D)
F) B) and C)

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You are working to characterize a novel protein in mice.Characterization of the mRNA expression pattern revealed that the gene is highly expressed in brain,muscle,liver,and pancreas.To determine the size of the corresponding protein,you make protein extracts from each of the tissues.Using an antibody that recognizes the C-terminal portion of the protein,you perform an analysis that allows you to visualize the extracted protein.Interestingly,you can detect the protein in brain,muscle,and liver,but not the pancreas.Assuming your extracts and reagents are good,and there is no human error,what is the most likely explanation for this result?


A) Transcription levels in pancreas are too low.
B) Translation levels in pancreas are too low.
C) Alternative splicing in the pancreas leads to protein degradation.
D) Alternative splicing in the pancreas yields a protein missing the portion of the protein to which the antibody was raiseD.

E) B) and D)
F) A) and B)

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Exists as a complex with many large proteins in ribosomes;many different kinds of molecules.


A) DNA
B) RNA polymerase
C) mRNA
D) rRNA

E) A) and B)
F) B) and D)

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